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KMID : 1101320040360020245
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Korean Journal of Clinical Laboratory Science
2004 Volume.36 No. 2 p.245 ~ p.251
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A Safety Experiment in Rats Exposed to BM-solution
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Kim Dong-Kyu
Kim Kee-Hyun
Lee Nam-Jin
Park Jong-Bae
Cho Jung-Hee
Kim Yun-Bae
Kang Jong-Koo
Kim Young-Kwon
Hwang Seock-Yeon
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Abstract
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This study was experiment on the safety of rat(Sprague-Dawley) exposed to natural herb oil(BM-solution). BM-solution was administered by inhalation to rats with the dose level of low(30 mg/8 min), middle(30 mg/4 min) and high(50 mg/4 min) in an airtight room for 4 weeks, respectively. Each groups, consisting of 5 rats, was examined for body weight changes, hematological analysis, serum biochemical analysis, organ weight, and histopathological findings, respectively. There were, dose-dependently, no changes of body weight and organ weights, no hematological anomalousness, and no other serum biochemical abnormality from the experiments. In addition, BM-solution was shown to have no specific toxicity by gross and histopathological findings. Therefore, it was concluded that BM-solution had no side effects on rats for 4 weeks.
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KEYWORD
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Natural herb oil, Hospital-acquired infection
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